How much income can you make as a life coach? The International Coach Federation (ICF) reported in 2007 that full-time coaches were earning an average of ?
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China's government and people have historically been friendly toward Linux, although not quite on the level of a new deal with Canonical. The country's Ministry of Industry and Information Technology is teaming with Canonical to create Ubuntu Kylin, a variant of the regular Linux distribution that would serve as a reference point for local hardware and software developers. A Raring Ringtail-based build due this April should bring Chinese calendars, character input methods and quick access to relevant music services. Later Kylin releases should integrate Baidu mapping, mass transit information, Taobao shopping and a common slate of photo editing and system tools from WPS. The hope is to foster open source development in China as part of a five-year government growth plan -- and, we suspect, get away from closed operating systems that Americans control.
Filed under: Software
Via: The Register
Source: Canonical
Source: http://www.engadget.com/2013/03/23/china-chooses-ubuntu-for-a-national-reference-os-coming-in-april/
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Facebook hasn't had a major, announcement-filled developer conference since September 2011's f8, and won't for the forseeable future. The Mobile DevCons it just announced won't have a ton of news, I hear, but will let developers meet Facebook staff and partners in New York, London, and Seoul at one-day gatherings this spring.Source: http://feedproxy.google.com/~r/Techcrunch/~3/r78d7o0EvyI/
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CHICAGO (AP) ? The mayor of a rural community in northern Illinois says residents are still coming to terms with the deaths of four high school students whose car skidded off a bridge into an icy creek.
Wilmington Mayor Marty Orr says it's a "tragic loss."
Will County Sheriff's Department spokesman Ken Kaupas (KOW'-puhs) says the bodies of the two boys and two girls, aged 15 to 17, were recovered Tuesday from Forked Creek near Wilmington.
Kaupas says the teens had been missing since Monday evening. Authorities don't know exactly when the accident occurred. Kaupas says the driver likely lost control after hitting a patch of water or ice. The car tore through a guard rail and plunged into the water.
Wilmington is 60 miles southwest of Chicago.
Source: http://news.yahoo.com/4-ill-teens-die-car-plunges-icy-creek-184646869.html
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Mar. 11, 2013 ? Researchers in the Evolutionary Bioinformatics Laboratory at the University of Illinois in collaboration with German scientists have been using bioinformatics techniques to probe the world of proteins for answers to questions about the origins of life.
Proteins are formed from chains of amino acids and fold into three-dimensional structures that determine their function. According to crop sciences professor Gustavo Caetano-Anoll?s, very little is known about the evolutionary drivers for this folding.
In collaboration with scientists at the Heidelberg Institute for Theoretical Studies, he has been working at the interface of molecular evolution and molecular dynamics, looking back to when proteins first appeared approximately 3.8 billion years ago to determine changes in folding speed over time.
To do this, they looked at all known protein structures as defined in the Structural Classification of Proteins (SCOP) database and mined their presence in 989 fully sequenced genomes. In a previous study, researchers in Caetano-Anoll?s's group used SCOP and genomic information to reconstruct phylogenomic trees that describe the history of the protein world. The current research is based on these types of trees.
"They are not the standard trees that people see in phylogenetic analysis," he said. "In phylogenetic analysis, usually the tips of the trees, the leaves, are organisms or microbes. In these, they are entire biological systems."
In contrast, the leaves of these new trees are protein domains, which are compact evolutionary units of structure and function. Proteins are usually complex combinations of several domains.
"We have a world of about 90,000 of these structures, but they seem to be always producing the same designs," he said. Over the last 10 years, he has been part of the effort to map these designs, or folds, because they are determined by the way the protein chains fold on themselves. To date, approximately 1,300 folds have been characterized.
For the current study, the researchers identified protein sequences in the genomes that had the same folding structure as known proteins. They then used bioinformatics techniques to compare them to each other on a time scale to determine when proteins became part of a particular organism. This allowed them to map protein structures and organisms onto a timeline.
Directly calculating the folding speed for all of these proteins would be impossible with today's technology, so the researchers took advantage of the fact that a protein always folds at the same points and used a measure called Size Modified Contact Order (SMCO).
Contact order is the ability of a protein to establish links between segments of the polypeptide chain. When points that are close together on the chain come together, they generally form helical structures; when distant points come together, they form beta strands that interact with each other and form sheets. Contact order measures how many of the connections are local and how many are distant. Experimental studies have shown that it is correlated with folding speed. The measure is normalized (size modified) to take protein length, which affects folding speed, into account.
They saw a peculiar pattern in the results.
"What we see is an hourglass," said Caetano-Anoll?s. "At the beginning, proteins seem not to be folding so fast. And then, as time progresses, there's a tendency to fold faster and faster. And then it reaches a critical point, and at this point we have a tendency that reverses, that seems to go back again to slow folding." However, the tendency toward higher speed dominates.
This point coincides with what he calls the "Big Bang" in protein evolution. Approximately 1.5 billion years ago, more complex domain structures and multi-domain proteins emerged with the appearance of multicellular organisms. Amino acid chains, which make up proteins, also became shorter at this point in time.
Why does folding speed matter?
"If the protein does not fold, in the vast majority of cases it will not have a function. So folding implies functionality. And speed of folding implies speed of achieving that functionality," he explained. "For a cell, that's very important, because if proteins are very slow folders, there is a time lag to when that function will be accessible to the cell."
Fast folders are also less susceptible to aggregation, or clumping together, so they work faster. Moreover, proteins that fold rapidly are more likely to fold correctly. Protein misfolding has been linked with diseases such as Alzheimer's.
Caetano-Anoll?s said, however, that this research makes an important contribution to understanding how molecules work. "The complexities of the biological functions of molecules are still poorly understood," he said.
"If we mix the world of molecular dynamics with the world of molecular evolution, we can then determine what aspects of sequences are important for molecular dynamics, and therefore, we can apply them to genetic engineering, synthetic biology, and so on."
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/RcBMjfLyCKk/130311101651.htm
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Source: http://www.austindailyherald.com/2013/03/11/county-to-discuss-change-to-retiree-health-insurance/
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Journalism?s top award, the Pulitzer Prize, gets a lot of attention when the winners are announced each year. But perhaps people should be paying more attention to public relations awards.
Because the people winning them are providing an ever-increasing share of what you read, see and download.
I was at the PR Week awards in New York City last week, the industry?s top competition. The agency I work for, Fast Horse, was a finalist for a couple of them. I put on a tuxedo and sat in a ballroom with hundreds of smart people who are very good at what they do. And what they?re good at is getting out their message at a time when the traditional media are less and less able to provide a counterweight.
Don?t take my word for it. Pro Publica, a nonprofit news organization, and the Columbia Journalism Review published a long article juxtaposing the rise of public relations with the decline of journalism. In it, journalists and academics laid out the facts showing how public relations is winning the battle for control of consumer content.
Consider:
?The muscles of journalism are weakening and the muscles of public relations are bulking up ? as if they were on steroids,? New York Times investigative reporter David Barstow told the authors.
But the story is more than just numbers. The change to digital communication has allowed corporations and organizations to bypass the traditional media gatekeepers and tell their story directly to the public in a way they never could before.
Do you get emails from political candidates you?ve given money to? Have you supported a cause on Facebook? Shared a photo about a product or an event? These are just a few examples of direct PR-driven communication.
If you?re looking for a recipe, are you more likely to find it in the newspaper food section ? or to visit? bettycrocker.com or one of the hundreds of food industry-sponsored sites eager to provide you with useful and entertaining cooking content?
The PR campaigns that were honored last week included traditional media relations ? successfully pitching stories that were reported in print and broadcast outlets. But far more prominent were non-traditional aspects of public relations: Facebook and Twitter campaigns, interactive games and contests, digital apps, documentary videos, mobile offers and more.
Public relations professionals are in the business of telling their clients? stories. Today, they have more tools than ever to do it. Meanwhile, a decade after the Internet revolution took hold in earnest, the traditional media are still struggling to remain relevant and make a profit in a media world turned upside down.
?The race is not always to the swift nor the battle to the strong,? Damon Runyon once wrote. ?But that?s the way to bet.?
Source: http://www.minnpost.com/business/2013/03/pr-winning-content-war
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Alec Baldwin, Tom Hanks, Chevy Chase, Steve Martin, Andy Samberg and Jay-Z support JT as he enters Five-Timers Club.
By Mary J. DiMeglio
Steve Martin and Justin Timberlake on "Saturday Night Live"
Photo: NBC/Broadway Video
Source: http://www.mtv.com/news/articles/1703356/justin-timberlake-snl.jhtml
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LAHORE, Pakistan (AP) ? Police have arrested around 150 people accused of burning dozens of Christian houses in eastern Pakistan after a non-Muslim was accused of making offensive comments about Islam's Prophet Muhammad, police said Sunday as Christians rallied against the destruction.
The Christian demonstrators blocked a main highway in Lahore and police fired tear gas shells to disperse the protesters who demanded assistance from the government.
Government spokesman Pervaiz Rasheed promised the government would help hem rebuild their houses, but the Christians expressed dissatisfaction with the way the government was handling the incident.
"I have been robbed of all of my life's savings," Yousuf Masih said, standing close to his burned house. He said the government's announcement that it would give 200,000 rupees ($2,000) compensation to each family was a joke.
The incident began on Friday after a Muslim accused a Christian man of blasphemy ? an offense that in Pakistan is punished by life in prison or death. On Saturday, a mob of angry Muslims rampaged through the Christian neighborhood, burning about 170 houses.
The Christian man is in police custody pending an investigation into the allegations.
Those who rioted are being investigated for alleged arson, robbery, theft, and terrorism, said police officer Abdur Rehman. The Pakistani police usually arrest rioters to tamp down public anger, but those accused are rarely convicted.
The law is often misused to settle personal scores and rivalries.
Akram Gill, a local bishop in the Lahore Christian community, said the incident had more to do with personal enmity between two men ? one Christian and one Muslim ? than blasphemy. He said the men got into a brawl after drinking late one night, and in the morning the Muslim man made up the blasphemy story as payback.
Such accusations of blasphemy in Pakistan can prompt huge crowds to take the law into their own hands. Once an accusation is made it's difficult to get it reversed, partly because law enforcement officials and politicians do not want to be seen as being soft on blasphemers.
According to Human Rights Watch, there are at least 16 people on death row for blasphemy and another 20 are serving life sentences.
Last year, there was a rare reversal of a blasphemy case. A teenage Christian girl with suspected mental disabilities was accused of burning pages of the Quran. But she was later released after a huge domestic and international outcry about her treatment. A local cleric where she lived was arrested and accused of planting the pages in her bag to incriminate her, a rare example of the accuser facing legal consequences. However, he was later freed on bail.
Also on Sunday, a suspected U.S. missile strike killed a foreign militant who was riding on horseback in Datta Khel in North Waziristan, according to three Pakistani intelligence officials who spoke anonymously because they were not authorized to talk to the media.
___
Associated Press Writer Rasool Dawar in Peshawar, Pakistan, contributed to this report.
Source: http://news.yahoo.com/pakistan-150-arrested-burning-christian-homes-092745787.html
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So, so, so many fights were announced in the past 24 hours. Here's a breakdown of what you will be seeing in coming months.
-- As you've seen from the front of Yahoo! Sports MMA, middleweight champion Anderson Silva's title bout with Chris Weidman at UFC 162 has been confirmed. It's Silva's second straight Fourth of July weekend card appearance. He won by TKO over Chael Sonnen last summer. Will he do the same against Weidman?
Also on that card will be Mark Munoz vs. Tim Boetsch, Rafael "Feijao" Cavalcante vs. Thiago Silva, and Roger Gracie vs. Tim Kennedy.
-- An injury to Alistair Overeem has forced his bout with Junior dos Santos off of UFC 160. The fight will likely take place later this summer.
-- In June, the UFC will head to Winnipeg for the first time for UFC 161. The card will be headlined with an interim bantamweight title belt bout between Renan Barao and Eddie Wineland. Also on that card, Rashad Evans will fight Dan Henderson, Antonio Rogerio Nogueira will fight Mauricio Rua, and Jake Shields will fight Tyron Woodley in a battle of Strikeforce vets.
-- Two bouts were also added to UFC on Fox 7 in April in San Jose. Flyweight Joseph Benavidez will fight Darren Uyenoyama, and Francisco Rivera will fight Hugo Viana in a bantamweight bout.
Want to get an early start on making picks? Take a chance in the comments, on Facebook or on Twitter.
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WASHINGTON (AP) ? House Speaker John Boehner says that President Barack Obama's recent outreach to congressional Republicans is a "hopeful sign" that progress could be made in breaking the recent impasse over how to reduce the federal deficit.
Boehner says at a news conference that it was interesting that after months of "campaign-style events" around the country to promote his agenda, that the president was now sitting down to talk to Republican lawmakers.
The Ohio Republican expressed optimism that the Obama's contacts with Republicans could be productive, adding that the president will not get very far if he insists on raising taxes.
Obama had dinner Wednesday with about a dozen GOP senators, and on Thursday was having lunch with the top House budget writers, including Republican Paul Ryan.
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by Rn T.Com
Join us on Saturday March 16th beginning at 9 a.m. for the first opportunity to purchase single game tickets for the 2013 season. The upcoming season features the most attractive promotional calendar ever and fans are encouraged to arrive early to get tickets for the special games they want.The 8.5 annual Redneck Rummage Sale will also be held the same day from 7 a.m. ? 2 p.m. Shoppers can find great bargains all day long from over 150 vendors.
Local favorite Thunderbolt Patterson will be on hand to entertain with live music during the event. Thunderbolt Patterson plays everything from classic rock to blues... something for everyone. Live music begins at 7 a.m. The world?s greatest Bloody Mary Maker will also be in attendance.
The Rome Braves home opener is April 6th against Savannah sand Gnats with the first pitch at 7 p.m. with gates opening at 6 p.m. Fans can enjoy a Fireworks Extravaganza after the game. Groups, parties, and picnics can be booked now by contacting the Rome Braves at 706-378-5100.
Click here to read additional press releases on RN-T.com.
Source: http://romenews-tribune.com/bookmark/21891261
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Source: http://blackandgoldpatrol.blogspot.com/2013/03/molecular-biology-definitions.html
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I've worked in the gay porn industry for over a decade -- producing, distributing, and making hardcore sex films. Two years ago, an unusual proposal came across my desk. A young filmmaker named Travis Mathews was looking to direct his first feature, a frank meditation on gay life in San Francisco called I Want Your Love, and he thought I might be able to help. He was looking for backers. It turned out, I could do a lot more.
We took on the project because we liked it. And because we were familiar with the gay market. But we also knew that we could give something to I Want Your Love that another, more traditional distributor couldn't: freedom.
From its early days, gay filmmaking has faced constraints when finding an audience that straight filmmakers don't. Earlier gay filmmakers, like Jack Smith and Kenneth Anger faced obscenity prosecution for even broaching the subject of sexuality. In the late '60s, even featuring someone in drag could result in an X rating. The culture has changed dramatically since then, but in some ways gay filmmakers still face challenges in bringing their movies to a market. Just this week, Australian censors banned I Want Your Love from screening at all in the country -- even at festivals.
It's too bad for them. I Want Your Love is a tremendous film, part meditation on gay identity, part love letter to San Francisco. It also happens to include segments with explicit gay sex. Watching the film evolve it struck me as to the difference between gay film and straight films. Unlike straight filmmakers that tend to play up the heat, gay filmmakers tend to de-sensationalize the sex, to make it seamless within a story, to play it down. Sex is an integral part of our lives, but that doesn't stop outsiders -- or traditional distributors -- from labeling it obscene or pornographic.
I Want Your Love has much in common with those early gay filmmakers -- and I think it also offers a way forward. Part of the reason I was so intrigued by the film as a producer was because I don't shy away from sex. And I knew that unlike mainstream distributors, we could help allow Travis to produce a version of the film that wasn't compromised by outdated ratings codes or theatrical discomfort. I Want Your Love screened at festivals across the country last year -- including a packed house at Lincoln Center, but when it's released this Monday, it's main distribution platform will be VOD -- video-on-demand.
Video-on-demand, a platform pioneered by porn companies like NakedSword, holds the possibility of a new era of gay filmmaking. Gay film festivals in places like New York, San Francisco and Provincetown will remain cultural events, but distribution -- the lifeblood of filmmaking -- will be increasingly virtual, allowing them to reach a larger and more targeted audience, and hopefully to finance their next project.
You see, porn hasn't had a theatrical revenue base for almost forty years. And what we've done in the meantime has been to build up email lists, to learn audience behaviors, and find ways to bypass the gatekeepers. We've always been the insurgents of the film community, with more in common with Roger Corman than any Burbank studio exec.
What does this mean for gay film? It means that our lives can be told in more varied, complex stories -- and still be profitable. It's like the difference between CBS and Netflix. To make a program successful, CBS needs to reach a broadest possible audience. Netflix, on the other hand, can create a successful production just by targeting a very specific segment of a larger audience. In many ways, this is what porn has been doing for years.
We're eager to help I Want Your Love find that audience, so that more stories like it can be told. People always ask me about the unlikely partnership between an indie filmmaker and a porn company. After all, if it were just about the money we could have made a more explicit film much more cheaply. So I tell them that it's not so much about the sex as it is the love -- for the audience, for the community, for the future of gay filmmaking.
?
Follow Tim Valenti on Twitter: www.twitter.com/NakedSwordTim
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Source: http://www.huffingtonpost.com/tim-valenti/i-want-your-love-gay-film_b_2819335.html
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I love hardware. That's why I want you guys to bring some of the coolest hardware projects imaginable to Disrupt NY?this?year. That's why I want you guys in our Hardware Alley.Source: http://feedproxy.google.com/~r/Techcrunch/~3/mSdWZOuBx1E/
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Ann Romney blames the media coverage for her husband's loss in the 2012 election. Ann Romney says "he wasn't given a fair shake" in the media.
Ann Romney tells Fox TV that Mitt Romney didn't get "a fair shake" in the media.Mitt Romney says his heart said he was going to win the presidency, but when early results came in on election night, he knew it was not to be. Ann Romney put a different spin on it:?I?m happy to blame the media.?
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The GOP nominee and his wife told? "Fox News Sunday" that he knew his campaign was in trouble when exit polls suggested a close race in Florida. Romney thought he'd win the state solidly.
Obama ended up taking Florida and won the election by a wide margin in the electoral vote. Romney says there was "a slow recognition" at that time that President Barack Obama would win ? and the race soon was over when Obama carried Ohio.
Romney says the loss hit hard and was emotional. Ann?Romney says she cried. ?The thing that was frustrating to me is that people didn?t really get to know Mitt for who he was,? she said. ?People weren?t allowed to see him for who he really was.?
"It was not just the campaign?s fault, I believe it was the media?s fault as well,? she told Chris Wallace. ?He was not being given a fair shake.?
The former Massachusetts governor acknowledged mistakes in the campaign and flaws in his candidacy.
But he joked that he did better in his second run for the White House than he did the first time around ? when he lost the 2008 nomination to Arizona Sen. John McCain.
He says he won't get a third crack at it.
Romney says his campaign didn't do a good job connecting with minority voters, and that Republicans must do a better job in appealing to African-Americans and Hispanics.
He says his campaign underestimated the appeal of Obama's new health care law to low-income voters.
But he knows that because he lost the race, it's hard to tell the GOP to listen now to what he has to say about how to improve the party's message.
The Romneys are living in Southern California now and he's kept a low profile since the election. He says "you move on" from the disappointment and that "I don't spend my life looking back."
Ann?Romney says that after the election she was approached by TV's "Dancing with the Stars," but declined to join the cast.
She says she'll be turning 64 soon and "I'm not really as flexible as I should be."
The interview was taped Thursday and aired Sunday.
Copyright 2013 The Associated Press.
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Mar. 5, 2013 ? For a bunch of inanimate chemical compounds, the nucleic and amino acids caught up in the infamous "selfish" segregation distorter (SD) saga have put on quite a soap opera for biologists since the phenomenon was discovered in fruit flies 50 years ago. A new study, a highlight in the March issue of the journal Genetics, provides the latest plot twist.
In TV listings the series would be described this way: "A gene exploits a rival gene's excesses, sabotaging any sperm that bear a rival's chromosome." The listing is not an exaggeration except for ascribing malicious intent to strings of biochemicals. When male flies make their sperm, the SD gene (call it "A") manages to rig meiosis -- the specialized cell division that makes sex cells -- so that maturing sperm that bear chromosomes with the susceptible allele (call that one "a") end up defective and discarded. They never even leave the testes.
It is murder of a sort. Similar selfish systems occur in mammals, including humans.
In the Genetics study conducted at Brown University, scientists uncover new clues about how the SD gene might be gaming the system against "a." It's a plot so fiendish, only an aggregation of genetic bases could evolve it. It also deepens biologists' understanding of an instance in which life violates a fundamental balance predicted by the father of genetics, Gregor Mendel.
"Mendel's first law is that different alleles of a gene will segregate," said Robert Reeenan, professor of biology and the study's senior author. "If we have two alleles -- big A and little a -- then Mendel says 50 percent of the sperm at random will get the big A and 50 percent of the sperm will get the little a. But some SD (A) alleles are so strong they pretty much kill off all the non-SD (a) chromosomes.
"This is a real cheater, a real stinker," Reenan said. "Most genes, like most people, are good upstanding citizens, but some genes want to hog all the resources, hog all the benefit."
The SD backstory
What makes the "a" allele susceptible to SD's subterfuge is the number of copies it harbors of a runaway snippet of genetic code called Responder. A few copies of Responder are no problem, but hundreds of copies make "a" susceptible. Some alleles have thousands of copies and only one in a thousand survives.
Genomes try to root out parasites like Responder by creating and dispatching proteins into the nucleus and the cytoplasm. These police proteins are armed with "police sketches" of the parasites in the form of small RNA transcripts.
The new plot twist
It struck Reenan and lead author Selena Gell that this policing system -- because it targets self-copiers like Responder -- might somehow have a role in the SD saga. They decided to find out by purposely perturbing the system.
In the experiments described in Genetics, Reenan and Gell show that engineered mutations in the police gene named Aubergine (others on the force in the experiments are called Piwi, Squash, and Zucchini) amplify SD chromosomes' success in eliminating Responder-laden sperm, compared to that of SD chromosomes without Aubergine's help. The results show that this police system suppresses Responder, and therefore SD. It also means that if SD somehow can upset the policing system, it can have a field day.
"We're the first to have experimentally shown that mutations in the system can modify the degree of distortion," Reenan said. "We used homologous recombination to knock in a mutation specifically on the SD chromosome to compromise Aubergine, and that's exactly what we saw: the chromosome became more selfish."
Reenan and Gell did not go so far as to determine whether known SD-promoting genes called Enhancer of SD, Stabilizer of SD, and Modifier of SD act by interfering with Aubergine or its buddies on the force, but Reenan said that is among the next things his group will look into.
In the meantime, he reflects, it may not be entirely fair for biologists to label SD as "selfish" and not Responder as well. As an out-of-control self-repeater in the genome, Responder is surely no prize, and SD performs something of a service by taking it out when it can.
The whole story is really a clash of the selfish. "Humans, flies, all of us have been attacked for millennia by selfish genetic elements that want to make as many copies as possible," Reenan said.
Sometimes, as in SD flies, there are no apparent ill effects, but when the selfish genes come in the form of viruses or other kinds of transposons, there can be trouble. So investigating the tactics of selfish genes is not merely the stuff of biological soap operas.
Gell, who was supported by a National Science Foundation Predoctoral Fellowship during the research, is now a postdoctoral scholar at Harvard University.
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The Dow Jones Industrial Average hit a record high Tuesday and as The Huffington Post's Mark Gongloff will tell you, it doesn't really matter. That's because while investors are cheering a return to boom times for Corporate America, real America still hasn't totally recovered from the Great Recession (which was, incidentally, kind of caused by Wall Street).
As these nine economic indicators reveal, things still haven't returned to the way they were in 2007 before the financial crisis.
(Editor's Note: We compared 2007 data to the most recent full-year data. This explains why some most up-to-date data is from 2011.)
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A couple of years ago there was an ambitious startup called Zoombu which concentrated on aggregating transport solution ?across platforms? ? in other words linking up trains, buses and airline time tables and allowing users to book. Indeed, the search engine - which launched in 2008 - was in much use during the ?Ash Cloud? incident in Europe in 2010 as people frantically tried to find over-land routes across the continent. But the heavy-lifting involved in aggregating all that data, combined with a difficult investment environment at the time meant that Zoombu's team took the 'acquihire' route, exiting to Skyscanner in 2011. Now a new player emerges today, attempting to do almost exactly the same thing - but this time GoEuro, based in Berlin, wil have a $4 million seed round to do it with.Source: http://feedproxy.google.com/~r/Techcrunch/~3/I-gDqysCxIU/
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